In response to requests for the funding of new drugs, reimbursement agencies are re-evaluating some of the methods used in assessing these products. Many trials submitted for the regulatory review of new drugs do not provide adequate data for subsidy decisions. The authors argue that all involved in bringing medicines to market need to be explicit about the additional information required, decide how these data should be collected and assessed and the methods that should be used to set a fair price for a new drug.
Equitable health services
Expensive medicines: ensuring objective appraisal and equitable access
Kennedy SB, Nisbett RA: Bulletin of the World Health Organization 93 (1), January 2014
Pharmaceutical Availability across Levels of Care: Evidence from Facility Surveys in Ghana, Kenya, and Uganda
Masters SH, Burstein R, DeCenso B, Moore K, Haakenstad A, et al: PLoS ONE 9(12), 31 December 2014
In this study the authors use facility-level data from nationally representative surveys conducted in Ghana, Kenya, and Uganda in 2012 to understand pharmaceutical availability within the three countries. The authors both availability of essential medicines, as defined by the various essential medicine lists (EMLs) of each respective country, and availability of all surveyed pharmaceuticals deemed important for treatment of various high-burden diseases, including those on the EMLs. The authors find that there is heterogeneity with respect to availability across the three countries with Ghana generally having better availability than Uganda and Kenya. They found that the factors associated with stock-out vary by country, but across all countries both presence of a laboratory at the facility and of a vehicle at the facility are significantly associated with reduced stock-out. The study highlights poor availability of essential medicines across these three countries and suggest more needs to be done to strengthen the supply system so that stock remains uninterrupted.
The Vaccine and Cervical Cancer Screen (VACCS) project: Acceptance of human papillomavirus vaccination in a school-based programme in two provinces of South Africa
Botha MH, Haynes van der Merwe F, Snyman LC, Dreyer G: South African Medical Journal 105(1), 28 November 2014
The incidence of cervical cancer in South Africa remains high, and the current screening programme has had limited success. New approaches to prevention and screening tactics are needed to investigate acceptance of school-based human papillomavirus (HPV) vaccination, as well as the information provided, methods of obtaining consent and assent, and completion rates achieved. Information on cervical cancer and HPV vaccination was provided to 19 primary schools in Western Cape and Gauteng provinces participating in the study. Girls with parental consent and child assent were vaccinated during school hours at their schools. A total of 3 465 girls were invited to receive HPV vaccine, of whom 2 046 provided written parental consent as well as child assent. Sufficient vaccination was achieved in 92% of the vaccinated cohort. The implementation project demonstrated that HPV vaccination is practical and safe in SA schools. Political and community acceptance was good, and positive attitudes towards vaccination were encountered. During the study, which mimicked a governmental vaccine roll-out programme, high completion rates were achieved in spite of several challenges encountered.
Where Do the Rural Poor Deliver When High Coverage of Health Facility Delivery Is Achieved? Findings from a Community and Hospital Survey in Tanzania
Straneo M, Fogliati P, Azzimonti G, Mangi S, Kisika F: PLoS ONE 9(12), December 2014
As part of maternal mortality reducing strategies, coverage of delivery care among sub-Saharan African rural poor will improve, with a range of facilities providing services. Whether high coverage will benefit all socio-economic groups is unknown. Iringa rural District, Southern Tanzania, with high facility delivery coverage, offers a place to address this question. Delivery services are available in first-line facilities (dispensaries, health centres) and one hospital. The authors assessed whether all socio-economic groups access the only comprehensive emergency obstetric care facility equally, and surveyed existing delivery services. Hospital population socio-demographic characteristics were compared to District population using multivariable logistic regression. Women from the hospital compared to the district population were more likely to be wealthier. Poorer women remain disadvantaged even where coverage is high, as they access lower level facilities and are under-represented where life-saving transfusions and caesarean sections are available.
Non-Communicable Disease on the rise in Uganda; Who is to blame?
Nsereko I: CEHURD newsletter December 2014
A recent survey carried out by the Center for Health, Human Rights and Development (CEHURD) with support from United Nations Development Program (UNDP) Uganda country office on the prevalence of risk factors for non communicable diseases among university students in and around Kampala found that up to 67% of the respondents did not know what NCDs were, 12% of students have used drugs, particularly Marijuana, 15% were current tobacco smokers, 9% smoked Shisha. More than 40% of the respondents were staying with parents who smoke, 10% have friends who smoke, 60% have smoked for less and 57% exposed to pro-cigarette advertisements. In areas where NCD services are available, these are often hampered by access to essential medicines.
A recent visit by the author to communities of Nyenga and Najja sub-counties of Buikwe district revealed that a huge percentage of the community members find no point in visiting health facilities for early screening for NCDs. The author suggests that government strengthen existing health facilities by providing essential NCD medicines and NCD screening services for at least all health center IVs.
Defining Motivational Intensity of Need for Family Planning in Africa
Kuang B, Ross J, Madsen EL: African Journal of Reproductive Health 18(3), September 2014
This study presents a new approach to defining high and low motivation groups of contraceptive users by stated intention to use, past use, and unmet need, to determine how these groups differ in characteristics and in region of residence. Data came from 23 DHS surveys in sub-Saharan countries. The low motivation non-users, with less past use and less intention to use in the future, are more rural, less educated, and closer to poverty. When used to guide planning, unmet need should be augmented with motivation, since the two classifications do not entirely overlap. Between 10 and 17 percent of current non-users of family planning are likely highly motivated to use, but are not captured in the unmet need classification. Programme implications for these non-using groups are discussed.
Universal health coverage and non-communicable diseases: a mutually reinforcing agenda
The NCD Alliance, October 2014
This policy brief analyses the relationships between Universal Health Coverage (UHC) and Non-Communicable Diseases (NCDs). It covers the unique challenges the NCD epidemic poses to achieving UHC, and the role of UHC in strengthening the NCD response. It also explores the implications and possible position of health, NCDs and UHC in the post-2015 development agenda. The key messages from the report include: UHC is a goal that all governments should commit to. It can help focus greater attention on coverage of quality services, health equity, and guar-anteeing financial-risk protection. The NCD epidemic poses unique challenges to the three dimensions of UHC. Access and availability to essential NCD services remains unacceptably low in many LMICs; major inequalities exist in terms of NCD risk, access to services, and health outcomes; and the epidemic imposes a huge economic burden on national budgets and can push households into poverty. Attainment of UHC will be dependent on prioritising NCD prevention and control in UHC design and implementation. When achieved, UHC can provide a powerful vehicle to accelerate progress on NCD outcomes, inequalities, and socio-economic impact. Lessons learnt from the NCD response can help support pathways to UHC. These include a focus on health promotion and prevention, multi-sectoral approach-es, addressing the social determinants of health, and domestic innovative financing mechanisms (including taxation on unhealthy products). For the post-2015 development agenda to be truly transformative for health, NCDs must be recognised as a priority and UHC must be articulated as a means to achieve improved health outcomes.
Using the unmet obstetric needs indicator to map inequities in life-saving obstetric interventions at the local health care system in Kenya
Echoka E, Dubourg D, Makokha A, Kombe Y, Olsen ØE, Mwangi M, Evjen-Olsen B and Byskov J: International Journal for Equity in Health 13(112), December 2014
Developing countries with high maternal mortality need to invest in indicators that not only provide information about how many women are dying, but also where, and what can be done to prevent these deaths. The unmet Obstetric Needs (UONs) concept provides this information. This concept was applied at district level in Kenya to assess how many women had UONs and where the women with unmet needs were located. A facility based retrospective study was conducted in 2010 in Malindi District, Kenya. Data on pregnant women who underwent a major obstetric intervention (MOI) or died in facilities that provide comprehensive Emergency Obstetric Care (EmOC) services in 2008 and 2009 were collected. The difference between the number of women who experienced life threatening obstetric complications and those who received care was quantified. The most common MOI was caesarean section, commonly indicated by Cephalopelvic Disproportion (CPD)–narrow pelvis. In absolute terms, 22 (11%) women in 2008 and 12 (6%) in 2009, who required a life saving intervention failed to get it. Deficits in terms of unmet needs were identified in rural areas.
Cervical Cancer Screening among University Students in South Africa: A Theory Based Study
Hoque ME, Ghuman S, Coopoosmay R, Van Hal G: PLoS ONE 9(11), 11 November 2014
Cervical cancer is a serious public health problem in South Africa. Even though the screening is free in health facilities in South Africa, the Pap smear uptake is very low. The objective of the study is to investigate the knowledge and beliefs of female university students in South Africa. A cross sectional study was conducted among university women in South Africa to elicit information about knowledge and beliefs, and screening history. A total of 440 students completed the questionnaire. Regarding cervical cancer, 55.2% had ever heard about it. Results indicated that only 15% of the students who had ever had sex and had heard about cervical cancer had taken a Pap test. Pearson correlation analysis showed that cervical cancer knowledge had a significantly negative relationship with barriers to cervical cancer screening. Susceptibility and seriousness score were significantly moderately correlated with benefit and motivation score as well as barrier score. Self-efficacy score also had a moderate correlation with benefit and motivation score. Students who had had a Pap test showed a significantly lower score in barriers to being screened compared to students who had not had a Pap test. This study showed that educated women in South Africa lack complete information on cervical cancer. Students who had had a Pap test had significantly lower barriers to cervical cancer screening than those students who had not had a Pap test.
Disrespectful and abusive treatment during facility delivery in Tanzania: a facility and community survey
Kruk M, Kujawski S, Mbaruku G, Ramsey K, Moyo W, Freedman L: Health Policy and Planning, 1 October 2014
Although qualitative studies have raised attention to humiliating treatment of women during labour and delivery, there are no reliable estimates of the prevalence of disrespectful and abusive treatment in health facilities. The authors measured the frequency of reported abusive experiences during facility childbirth in eight health facilities in Tanzania and examined associated factors. The study was conducted in rural northeastern Tanzania, using a structured questionnaire. A total of 1779 women participated in the exit survey and 593 were re-interviewed at home. Between 19% and 28% of women in eight facilities in northeastern Tanzania experienced disrespectful and/or abusive treatment from health providers during childbirth. This is argued by the author to be a health system crisis that requires urgent solutions both to ensure women’s right to dignity in health care and to improve effective utilization of facilities for childbirth in order to reduce maternal mortality.