This study examined pre-eclampsia management in Sierra Leone and Zambia, where the condition contributes significantly to maternal mortality (70% of 30,000 annual deaths occur in Sub-Saharan Africa). The authors implemented policy labs, a user-centric approach bringing together diverse stakeholders to integrate new evidence into care pathways. Working with the Policy Institute and local stakeholders, the labs focused on improving timely detection and early delivery strategies for pre-eclampsia cases. Participants identified lack of awareness as a key barrier and recommended locally co-designed community strategies to increase access to timely management. The policy lab approach proved effective in both settings for translating new knowledge into policy and action.
Monitoring equity and research policy
This qualitative pre-post evaluation study examined the transition to an electronic Research Ethics Information Management System at Muhimbili University through interviews with 16 faculty members with experience in both paper-based and electronic systems. Using thematic analysis, researchers identified key strengths including system convenience and improved records management. Limitations centered on demands for reliable information and communication technologies and reduced reviewer-researcher interaction. The findings underscore both benefits and challenges of implementing paperless systems in resource-limited settings, recommending system automation, strengthened institutional capacity, and further studies on system adoptability, particularly in resource-constrained environments.
This paper assessed the World Health Organization’s approaches to health equity in select health promotion, social determinants of health, and urban health texts from 2008 to 2016. The authors found that the World Health Organization usually measures health equity by comparing groups, explicitly specifies three approaches to health equity and considers health equity inconsistently both in terms of socioeconomic status and other social determinants of health. Socioeconomic status was given substantially more attention than other social determinants of health. The authors argue that there is misalignment with the World Health Organization’s stated approaches to tackle health inequity and its discourses around health equity. This incongruence, they argue, increases the likelihood of pursuing short-term solutions and not sustainably addressing the root causes of health inequity. They argue that critical discourse analysis’ focus on power allowed for an understanding of why ‘radical’ approaches are not explicitly expressed so that governments will be agreeable to addressing health inequity.
The world faces global health risks that need to be effectively addressed in integrated, participatory efforts. However, risk analysis frameworks do not account for the complex nature of systems that span multiple sectors or disciplines. The authors propose the participatory and interdisciplinary concept of risk negotiation to transform the way global health challenges such as pandemics, physical and mental health inequities, environmental problems and food security are tackled. To allow such risk analysis, there is a need to recognize the value of risks and trade-offs and negotiate them with stakeholder groups representing different disciplines and sectors. This approach becomes feasible through recent technological breakthroughs such as artificial intelligence-assisted multi-agent negotiations or large language models. These models are accessible, hold promise in negotiating agreements and can be used to accommodate the complexity of real-world decision-making.
Sub-Saharan Africa has the highest under-five mortality rate globally and child healthcare decisions should be based on rigorously developed evidence-informed guidelines. The Global Evidence, Local Adaptation (GELA) project is enhancing capacity to use global research to develop locally relevant guidelines for newborn and child health in South Africa (SA), Malawi, and Nigeria. The first step, described in this paper, identifies national priorities for newborn and child health guideline development. This followed a good practice method for priority setting, including stakeholder engagement, online priority setting surveys and consensus meetings, conducted separately in South Africa, Malawi and Nigeria. The authors established national Steering Groups, comprising 10–13 members representing government, academia, and other stakeholders, identified through existing contacts and references, who helped prioritise initial topics identified by research teams and oversaw the process. Various stakeholders were consulted via online surveys to rate the importance of topics, with results informing consensus meetings with Steering Groups where final priority topics were agreed. Through voting and discussion within meetings, and further engagement after the meetings, the top three priority topics were identified in each country. In South Africa, the topics concerned anemia prevention in infants and young children and post-discharge support for caregivers of preterm and low birth weight babies. In Malawi, they focused on nutrition in critically ill children, diagnosis of childhood cancers in the community, and caring for neonates. In Nigeria, the topics focused on identifying pre-eclampsia in the community, hand hygiene compliance to prevent infections, and nutrition for low both weight and preterm infants.
This paper compiles current evidence on barriers to uptake of research in health policy and practice in low- and middle-income countries using scoping review. A total of 4291 publications were retrieved in the initial search, of which 142 were included as meeting the eligibility criteria. Overall, research uptake for policy-making and practice in low- and middle-income countries was very low. The challenges to research uptake were related to lack of understanding of the local contexts, low political priority, poor stakeholder engagement and partnership, resource and capacity constraints, low system response for accountability and lack of communication and dissemination platforms. Important barriers to research uptake were identified, particularly limited contextual understanding and low participation of key stakeholders and ownership. The authors suggest improved understanding of the local research and policy context and participatory evidence production and dissemination to promote research uptake for policy and practice. Institutions that bridge the chasm between knowledge formation, evidence synthesis and translation are noted to potentially play critical role in this translation process.
The COVID-19 pandemic lockdown and restrictions on movement presented an opportunity to conduct Violence Against Women (VAW) research using remote methods. The authors discuss how they adapted methods, reflect on lessons learned, and make recommendations highlighting key considerations when conducting remote research on a sensitive topic of VAW. An exploratory qualitative study was designed using remote methods with 18 men and 19 women, aged 18 years and older, who lived with their partner or spouse during lockdown in South Africa. Data presented in this paper draws from researchers’ reflections drawn from debriefing sessions during the research process, and from participants’ interview transcripts. Remote recruitment of participants took longer than anticipated, and the authors had to re-advertise the study. The authors could not ensure safety and privacy during interviews. Regardless of all the safety and privacy measures the authors put in place during the research process, some participants had an adult person present in the room during interviews, and the researchers had no control over interruptions. Rapport was difficult to establish without an in-person connection, which limited disclosure about violence experience and perpetration. Given the methodological and ethical challenges which limited disclosure of violence against women remotely, the authors conclude that telephone interviews used in this study impacted on the quality of study data. Therefore, the authors do not recommend violence against women research to be conducted remotely, unless it is essential and participants are already known to the interviewer and trust has been established.
This study aimed to understand how much more demographic health surveys can reveal about Zambia’s progress in reducing inequalities in under-five mortality rates and reproductive, maternal, newborn and child health intervention coverage, using four nationally-representative Zambia Demographic Health Surveys, comparing wealth quintiles, urban‐rural residence and provinces, and further using multi-tier measures including wealth deciles and double disaggregation between wealth and region. Comparing measures of inequalities over time, disaggregation with multiple socio-economic and geographic stratifiers was often valuable and provided additional insights compared to conventional measures. Wealth quintiles were sufficient in revealing mortality inequalities compared to deciles, but comparing composite coverage indices by deciles provided more nuance by showing that the poorest 10% were left behind by 2018. Examining wealth in only urban areas helped reveal closing gaps in under-five mortality and composite coverage indices between the poorest and richest quintiles. Though challenged by lower precision, wealth gaps appeared to close in every province for both mortality and composite coverage indices. Still, inequalities remained higher in provinces with worse outcomes. Multi-tier equity measures provided similarly plausible and precise estimates as conventional measures for most comparisons, except mortality among some wealth deciles, and wealth tertiles by province. This suggests that related research could readily use these multi-tier measures to gain deeper insights on inequality patterns for both health coverage and impact indicators, given sufficient samples.
Through sustainable development goals 3 and 8 and other policies, countries have committed to protect and promote workers’ health by reducing the work-related burden of disease. However, while injuries are well monitored, the World Health Organization and the International Labour Organization estimate that only 363 283 (19%) of 1 879 890 work-related deaths globally in 2016 were due to injuries, whereas 1 516 607 (81%) deaths were due to diseases. To address this gap, the authors present a new global indicator: mortality rate from diseases attributable to selected occupational risk factors, by disease, risk factor, sex and age group. The authors outline the policy rationale of the indicator, describe its data sources and methods of calculation, and report and analyse the official indicator for 183 countries. They also provide examples of the use of the indicator in national workers’ health monitoring systems and highlight the indicator’s strengths and limitations.
The four countries in this mixed-methods observational and desk review study were selected based on their variability in COVID-19 response and representation of Francophone and Anglophone countries. The research documented best practices, gaps, and innovations in surveillance at the national, sub-national, health facilities, and community levels, and these learnings were synthesized across the countries. As the pandemic progressed, the health systems moved from aggressive testing and contact tracing to detect virus and triage individual contacts into quarantine and confirmed cases, isolation and clinical care. Surveillance, including case definitions, changed from contact tracing of all contacts of confirmed cases to only symptomatic contacts and travellers. All countries reported inadequate staffing, staff capacity gaps and lack of full integration of data sources, and improved surveillance capacity by training health workers and increasing resources for laboratories, but the disease burden was still under-detected, due to limited decentralization of surveillance at the subnational level and gaps in genomic and post-mortem surveillance, community level sero-prevalence studies, and in digital technologies to provide more timely and accurate surveillance data. The authors call for investments to enhance surveillance approaches and systems including decentralizing surveillance to the subnational and community levels, strengthening capabilities for genomic surveillance and use of digital technologies, investing in health worker capacity, ensuring data quality and availability and improving ability to transmit surveillance data between and across multiple levels of the health care system.