A paper developed by the Health Systems Resource Centre on behalf of the Department for International Development (DFID) and in collaboration with the World Health Organisation (WHO) aims to increase understanding of the requirements for introducing and scaling up provision of antiretroviral therapy (ART) as part of comprehensive HIV/AIDS programmes in resource-poor countries. The paper provides an overview of experience and lessons learned with regard to: The feasibility of ART in resource-poor settings; The different approaches being taken to delivery of ART; and The issues to be considered in scaling up ART provision. The review is based on published and unpublished literature, interviews with key informants, web searches and country information.