An ongoing Phase 3 study of the efficacy, safety and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries, including Ghana, Kenya, Malawi, Mozambique and Tanzania. From March 2009 through January 2011, 15,460 children were enrolled in two age categories - 6 to 12 weeks and 5 to 17 months old - for vaccination with either RTS,S/AS01 or a non-malaria comparator vaccine. After 250 children had an episode of severe malaria, researchers evaluated vaccine efficacy in both age categories. Vaccine efficacy in the combined age categories was 34.8% during an average follow-up of 11 months. Serious adverse events occurred with a similar frequency in the two study groups. Among children in the older age category, the rate of generalised convulsive seizures after vaccination was 1.04 per 1,000 doses. The researchers conclude that the RTS,S/AS01 vaccine provided protection against both clinical and severe malaria in African children.
Equitable health services
The authors of this paper argue that the importance of strong health care systems to fragile nations and the damage done to these systems during conflict receive less attention than they should. They note that the impact of the cycle of violence and poverty on health and health care in fragile states is enormous, to the extent that no low-income fragile or conflict-affected country has yet achieved a single Millennium Development Goal. Although the international community spends billions of dollars each year in aid to these nations, gains have generally been small – without infrastructure and stability, much of this aid is wasted. In conclusion, the authors argue that adequate and equitable provision of quality health care will be met only if health systems and structures are preserved and developed, and if health care personnel have the freedom and safety to provide necessary care to those who need it.
The purpose of this paper was to assess the epidemiology of endemic health care-associated infection (HAI) in Africa. Three databases (PubMed, the Cochrane Library, and the WHO regional medical database for Africa) were searched, of which 19 articles were included in this study, and four abstracts of leading international infection control conferences were also included. The hospital-wide prevalence of HAI varied between 2.5% and 14.8%; in surgical wards, and the cumulative incidence ranged from 5.7% to 45.8%. The largest number of studies focused on surgical site infection, whose cumulative incidence ranged from 2.5% to 30.9%. Data on causative pathogens were available from a few studies only and highlighted the importance of Gram-negative rods, particularly in surgical site infection and ventilator-associated pneumonia. The authors note that limited information is available on the endemic burden of HAI in Africa, even though its frequency is much higher than in developed countries. There is an urgent need to identify and implement feasible and sustainable approaches to strengthen HAI prevention, surveillance and control in Africa.
To demonstrate how reforms at Makerere University College of Health Sciences (MakCHS) can lead to making systemic changes that can improve maternal health services, the university has developed a demand and supply side strategy by working with local communities and national stakeholders. This quasi-experimental trial was conducted in two districts in Eastern Uganda. The supply side component included health worker refresher training and additions of minimal drugs and supplies, whereas the demand side component involved vouchers given to pregnant women for motorcycle transport and the payment to service providers for antenatal, delivery and postnatal care. Analysis from routine health information systems showed that motorcyclists in the community organised themselves to accept vouchers in exchange for transport for maternal care and have become actively involved in ensuring that women obtain care. Maternal care improved, with the number of safe deliveries in the intervention area immediately jumping from less than 200 deliveries/month to over 500 deliveries/month in the intervention arm. Voucher revenues were used to obtain needed supplies and to pay health workers, ensuring their availability at a time when workloads are increasing. The researchers conclude that transport and service vouchers appear to be a viable strategy for rapidly increasing maternal care.
This briefing paper provides an overview of existing literature on the mental health effects of sexual violence and rape, a summary of effective interventions, and outlines a brief research agenda for mental health responses to sexual violence in resource-poor settings. The authors found that, in resource-poor settings, most efforts to strengthen responses to survivors of sexual violence have so far focused on the training of specialised staff based in hospitals or crisis centres who administer limited services – immediate care and a forensic exam – before referring patients to mental health practitioners or social workers for mental health interventions, if the latter are available. Most therapies and treatments for mental health problems have been implemented in the developed world and may require multiple counselling sessions over the long-term with professional staff, but developing countries generally lack capacity to provide psychological interventions. Of the various approaches, evidence consistently points to cognitive behavioural therapies as being more effective in reducing symptoms of post-traumatic stress than counselling. Sexual violence is an under-researched area across the globe but there is a particular lack of research from resource poor countries on the mental health aftermath of sexual violence. The authors call for further research, providing a basic research agenda at the end of the paper.
In this study, researchers examined the factors associated with use of nets owned in Ghana. The data was derived from an August 2008 survey in Ghana of households with a pregnant woman or a guardian of a child under five, conducted during the rainy season. A total of 1,796 households were included, which generated a sample of 1,852 mosquito nets. The final multivariate model consisted of ten variables statistically associated with whether or not the net was used the prior night: rural location, lower socio-economic status, not using coils for mosquito control, fewer nets in the household, newer nets and those in better condition, light blue colour, higher level of education of the guardian of the child under five, knowing that mosquitoes transmit malaria, and paying for the net instead of obtaining it free of charge. The results of this study suggest that net use would increase in Ghana if coloured nets were made available in mass distributions as well as in the commercial market; if programmes emphasise that malaria is caused only by night-biting mosquitoes, and that nets protect against mosquitoes better than coils and need to be used even if coils are burning; if donated nets are replaced more frequently so that households have nets that are in good condition; and if there were support for the commercial market so that those who can afford to purchase a net and want to choose their own nets can do so.
The aim of this paper was to describe the pre-operative surgical case mix among patients undergoing cataract extraction and explore associations between case mix, country level of development (as measured by the Human Development Index, or HDI) and cataract surgery rates (CSRs). Ophthalmologists at 112 eye hospitals (54% of them non-governmental) in 50 countries provided data on 11,048 cataract procedures over nine months in 2008. Patients whose visual acuity (VA) before surgery was < 6/60 in the better eye comprised 47% of the total case mix in poorly developed countries and 1% in developed countries. Overall, 72% of the eyes undergoing surgery had a VA < 6/60. Very low VA before cataract surgery was strongly associated with poor development at the country level and inversely associated with national CSRs. The researchers conclude that the proportion of patients with very poor preoperative VA is a simple indicator that can be easily measured periodically to monitor progress in ophthalmological services. Additionally, the internet can be an effective tool for developing and supporting an ophthalmological research network capable of providing a global snapshot of service activity, particularly in developing countries.
The aim of this paper is to show that current provider-centred models of chronic care are not adequate and to propose 'full self-management' as an alternative for low-income countries. People with chronic life-long conditions need to 'rebalance' their life in order to combine the needs related to their chronic condition with other elements of their life, the authors argue. They have a crucial role in the management of their condition and the opportunity to gain knowledge and expertise in their condition and its management. Therefore, people with chronic life-long conditions should be empowered so that they become the centre of management of their condition. In full self-management, patients take full responsibility for their condition, supported by peers, professionals and information and communication tools. The authors examine two current trends to enhance the capacity for self-management and coping: the emergence of peer support and expert-patient networks, and the development and distribution of smart phone technology.
Modern medicine is often accused by diverse critics of being ‘too materialistic’ and therefore insufficiently holistic and effective. Yet, this critique can be misleading, the authors of this paper argue, as it is dependent upon the ambiguous meanings of ‘materialism’. The term can refer to the prevalence of financial concerns in driving medical practice or it can refer to ‘mechanistic materialism,’ the patient viewed as a body-machine. In each case, this article shows that this represents not authentic ‘materialism’ at play, but a focus upon high-level abstractions. ‘Bottom-line’ financial or diagnostic numbers can distract practitioners from the embodied needs of sick patients. In this sense, medical practice is not materialist enough. Through a series of clinical examples, the authors explore how an authentic materialism would look in current and future practice. They examine the use of prayer/comfort shawls at the bedside, the redesign of hospitals and nursing homes as enriched healing environments, and a paradigmatic medical device - the implantable cardioverter defibrillator - as it might be presented to patients, in contrast to current practice.
The authors of this study examined the feasibility of using community health workers (CHWs) to implement cardiovascular disease (CVD) prevention programmes within faith-based organisations in Accra, Ghana. Faith-based organisation capacity, human resources, health programme sustainability/barriers and community members’ knowledge were evaluated. Data on these aspects were gathered through a mixed method design consisting of in-depth interviews and focus groups with 25 church leaders and health committee members from five churches, and of a survey of 167 adult congregants from two churches. Findings indicated that the delivery of a CVD prevention programme in faith-based organisations by CHWs is feasible. Many faith-based organisations already provide health programmes for congregants and involve non-health professionals in their health-care activities, and most congregants have a basic knowledge of CVD. Yet despite the feasibility of the proposed approach to CVD prevention through faith-based organisations, sociocultural and health-care barriers such as poverty, limited human and economic resources and limited access to health care could hinder programme implementation.